Lymphocytoma cutis (pseudolymphoma)Lymphocytoma cutis (pseudolymphoma) is a benign polyclonal proliferation of lymphocytes in the skin that presents as infiltrated pink-red to red-purple papules and plaques; it must be distinguished from lymphoma cutis. Lymphoma cutis can occur anywhere on the surface of the skin, whereas the sites of predilection for lymphocytomas include the malar ridge, tip of the nose, and earlobes. Additional disorders in the differential diagnosis of red papules/plaques include erysipelas, polymorphous light eruption (PMLE), lymphocytoma cutis, cutaneous lupus, lymphoma cutis, and leukemia cutis. Leukemia cutis has the same appearance as lymphoma cutis, and specific lesions are seen more commonly in monocytic leukemias than in lymphocytic or granulocytic leukemias. In lymphoma cutis there is a proliferation of malignant lymphocytes or histiocytes in the skin, and the clinical appearance resembles that of lymphocytoma cutis¾infiltrated pink-red to red-purple papules and plaques. Patients with non-Hodgkin's lymphomas have specific cutaneous lesions more often than those with Hodgkin's disease, and occasionally, the skin nodules precede the development of extracutaneous non-Hodgkin's lymphoma or represent the only site of involvement. Arcuate lesions are sometimes seen in lymphoma and lymphocytoma cutis as well as in CTCL. |
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